The major histocompatibility complex (MHC) is central for self-/non–self-recognition and acquired immunity. The extreme polymorphism of MHC genes, promoted by parasite-mediated selection, contrasts with limited within-individual diversity. The prevailing explanation is a trade-off between increased pathogen recognition and the anti-autoimmune T cell receptor (TCR) depletion mechanism. However, the predicted inverse relationship between individual MHC diversity and TCR repertoire size has not yet been shown. Using a rodent species with a variable number of MHC genes, we detected such an effect for MHC class I, but not class II. Our results, reported in PNAS (Migalska, Sebastian & Radwan 2019), partially support the TCR depletion hypothesis, but also suggest additional, unexplored mechanisms that might be constraining expansion of the MHC gene family.
- SEMINARS ON EVOLUTION, ECOLOGY & BEHAVIOUR 23 January 2020
- SEMINARS ON EVOLUTION, ECOLOGY & BEHAVIOUR 16 January 2020
- Article in Ecology Letters authored by Michał Bogdziewicz 20 December 2019
- SEMINARS ON EVOLUTION, ECOLOGY & BEHAVIOUR 9 December 2019
- Michał Bogdziewicz from our Institute published an article in Nature Plants! 9 December 2019
- SEMINARS ON EVOLUTION, ECOLOGY & BEHAVIOUR 21 November 2019